环磷酰胺对全胚胎培养小鼠胚胎的细胞学影响

doi:10.3969/j.issn.1004-616x.2000.03.006

Carcinogenesis, Teratogenesis & Mutagenesis ›› 2000, Vol. 12 ›› Issue (3): 145-148.doi: 10.3969/j.issn.1004-616x.2000.03.006

Previous Articles Next Articles

CELLULAR EFFECTS OF CYCLOPHOSPHAMIDE ON MOUSE EMBRYOS FROM WHOLE EMBRYO CULTURE SYSTEM

GUAN Xiao - ju , et al

Instit ute of Im munology , Thi rd Military Medical University , Chongqing 400038 , China

Received:1999-07-25 Revised:2000-01-13 Online:2000-07-30 Published:2000-07-30

Abstract

Abstract: Purpose and Methods : By using mouse whole embryo culture technique , the in vit ro model of cyclophosphamide - induced teratogenicity was established. The cellular effects of cyclophosphamide on mouse embryos was evaluated by light microscopy and flow cytomet ry. Results and Conclusion : The result s suggested that the variation of cell cycle and the occurrence of apoptosis might be involved in cyclophosphamide - induced teratogenicity.

Key words: cyclophosphamide, whole embryo culture, cell cycle, apoptosis

CLC Number:

R968

GUAN Xiao - ju , et al. CELLULAR EFFECTS OF CYCLOPHOSPHAMIDE ON MOUSE EMBRYOS FROM WHOLE EMBRYO CULTURE SYSTEM[J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2000, 12(3): 145-148.

[1]	LI Boru, QIN Shuangjian, GUAN Lan, LI Runbing, CAI Ying, PU Jiening, ZENG Ming, XIAO Fang, XU Xinyun. Effects of PM_2.5 on oxidative damage and apoptosis in HK-2 cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(5): 360-364.
[2]	HUANG Xiaohua, NIU Yongdong, SHI Ganggang. Inhibitory effects and mechanisms of nuclear receptor FXR activation in cervical cancer cell line CaSki [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(4): 302-306.
[3]	LIU Qingyun, KANG Chenping, XIAO Qianqian, HAO Weidong. Developmental toxicity of cerium nitrate in post-implantation whole embryo cultures using a micro-mass test [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(3): 178-186,207.
[4]	WANG Xikai, MENG Qinghe, GAO Yanlu. miR-223-3p negatively regulated ECT2 to induce apoptosis in non-small cell lung cancer cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(3): 187-192.
[5]	LI Boru, QIN Shuangjian, LI Runbing, CAI Ying, ZHENG Kai, ZENG Ming, XIAO Fang, XU Xinyun. Effects of p38MAPK gene on PM_2.5-induced expression of oncogenes and apoptosis genes in HK-2 cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(2): 129-135,142.
[6]	MA Shunpeng, WANG Quankai, WANG Miao, SONG Jiayang, WUHAN Baolier, XIE Guangyun, XU Jianning. Long non-coding RNA regulates apoptosis during glycidyl methacrylate-induced malignant transformation of 16HBE cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(1): 1-5,31.
[7]	LI Boru, QIN Shuangjian, LI Runbing, CAI Ying, ZHENG Kai, WANG Bingyu, ZENG Ming, XIAO Fang, XU Xinyun. Effects of PM_2.5 exposure on expression of oncogenes and apoptosis genes in human renal epithelial cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(1): 6-11.
[8]	HUANG Lili, ZHANG Mengyun, LIU Keliang, PANG Dingguo, LIU Lida, XU Peiyu. Hepatotoxicity of 2,4-dichlorophenoxyacetic acid in young SD rats [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(1): 22-27.
[9]	CUI Zhaoyang, LI Suna, JIANG Xuqian, WANG Yidan, HOU Liying. Activation of the TRAIL death receptor by apigenin for induction of apoptosis in the gastric cancer SGC-7901 cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2021, 33(1): 32-36.
[10]	LAN Li, CHEN Haili, XU Lei. Mechanism of RBMS3-S3 on the proliferation, apoptosis and invasion of cervical cancer cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(6): 438-443.
[11]	LIU Peng, BAI Yixiao. Effect of miR-29a on proliferation and migration of human gastric cancer cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(6): 452-456,463.
[12]	KANG Chenping, LIU Qingyun, XIAO Qianqian, HAO Weidong. Developmental toxicity of lanthanum nitrate in post-implantation whole embryo culture and micromass test [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(4): 256-263,268.
[13]	YANG Xingxiao, ZHANG Xueyuan, ZOU Naiyi, SHAN Bao'en, MA Ming, ZHU Shuchai. Effect of HMGB1 silencing by siRNA on radiosensitivity of esophageal carcinoma KYSE30 cells [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(4): 269-274.
[14]	QIN Shuangjian, LI Boru, CAI Ying, ZHENG Kai, WANG Bingyu, LI Runbing, XIAO Fang, ZENG Ming, XU Xinyun. PM_2.5 exposure on expression of oncogenes and apoptosis genes in hepatocytes [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(4): 281-285.
[15]	CAI Ying, ZHENG Kai, QIN Shuangjian, LI Boru, YU Shuyuan, LIU Ning, JI Jiajia, ZHANG Zhaohui, XU Xinyun. Silencing of c-fos gene on expression of oncogenes and apoptosis genes in HBE cells exposed to PM_2.5 [J]. Carcinogenesis, Teratogenesis & Mutagenesis, 2020, 32(4): 298-303,308.

CELLULAR EFFECTS OF CYCLOPHOSPHAMIDE ON MOUSE EMBRYOS FROM WHOLE EMBRYO CULTURE SYSTEM

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments